• Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women 

      Frydenberg, Hanne; Flote, Vidar Gordon; Larsson, Ine Marie; Barrett, Emily S.; Furberg, Anne-Sofie; Ursin, Giske; Wilsgaard, Tom; Ellison, Peter; McTiernan, Anne; Hjartåker, Anette; Jasienska, Grazyna; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
      Introduction: Alcohol consumption may promote aromatization of androgens to estrogens, which may partly explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women remains unclear.<p> <p>Methods: Alcohol consumption was collected by self-report ...
    • Dietary changes in early-stage breast cancer patients from pre-surgery and over the 12 months post-surgery 

      Brunvoll, Sonja Hjellegjerde; Thune, Inger; Bertheussen, Gro Falkener; Fjeldheim, Frøydis Nyborg; Flote, Vidar Gordon; Frydenberg, Hanne; Lundgren, Steinar; Skjerven, Helle; Lømo, Jon; Fagerland, Morten; McTiernan, Anne; Schlichting, Ellen; Hjartåker, Anette (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-19)
      The time after a breast cancer diagnosis is a potential period for making positive dietary changes, but previous results are conflicting. The main aim of the present study was to study breast cancer patients’ dietary changes during the 12 months post-surgery and from 12 months pre-surgery to 12 months post-surgery with repeated administration of a 7-d pre-coded food diary and an FFQ, respectively. ...
    • Gene variations in oestrogen pathways, CYP19A1 , daily 17ß-estradiol and mammographic density phenotypes in premenopausal women. 

      Flote, Vidar Gordon; Furberg, Anne-Sofie; McTiernan, Anne; Frydenberg, Hanne; Ursin, Giske; Iversen, Anita; Lofterød, Trygve; Ellison, Peter T.; Wist, Erik; Egeland, Thore; Wilsgaard, Tom; Makar, Karen W; Chang-Claude, Jenny; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-19)
    • Genetic Polymorphism CYP17 rs2486758 and Metabolic Risk Factors Predict Daily Salivary 17 beta-Estradiol Concentration in Healthy Premenopausal Norwegian Women. The EBBA-I Study 

      Iversen, Anita; Thune, Inger; McTiernan, Anne; Makar, Karen W; Wilsgaard, Tom; Ellison, Peter T.; Jasienska, Grazyna; Flote, Vidar Gordon; Poole, Elizabeth M; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-14)
      Context: The relationship between low-penetrance genes, metabolic risk factors, and levels of endogenous 17β-estradiol and progesterone, which play a role in breast cancer risk, remains unclear. <br>Objective: The aim of this study was to determine whether common polymorphisms in CYP17, in combination with metabolic risk factors (individually or clustered), alter salivary concentrations of free ...
    • Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes 

      Lofterød, Trygve; Mortensen, Elin Synnøve; Nalwoga, Hawa; Wilsgaard, Tom; Frydenberg, Hanne; Risberg, Terje; Eggen, Anne Elise; McTiernan, Anne; Aziz, Sura Mohammed; Wist, Erik; Stensvold, Andreas; Reitan, Jon Brinchmann; Akslen, Lars A.; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-15)
      <i>Background</i>: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.<p> <p><i>Methods</i>: A population-based survival study among 464 breast cancer cases ...
    • Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer 

      Vaysse, Charlotte; Lømo, Jon; Garred, Øystein; Fjeldheim, Frøydis Nyborg; Lofterød, Trygve; Schlichting, Ellen; McTiernan, Anne; Frydenberg, Hanne; Husøy, Anders; Lundgren, Steinar; Fagerland, Morten W; Richardsen, Elin; Wist, Erik; Muller, Catherine; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)
      Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures ...
    • Inflammatory serum markers and risk and severity of prostate cancer: The PROCA‐life study 

      Stikbakke, Einar; Richardsen, Elin; Knutsen, Tore; Wilsgaard, Tom; Giovannucci, Edward L; McTiernan, Anne; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      Whether chronic inflammation mirrored by high levels of systemic inflammatory markers such as high sensitive‐CRP (hs‐CRP) and white blood cell count (WBC) are associated with prostate cancer development remains unclear. In the Prostate Cancer Study throughout Life (PROCA‐<i>life</i>), a prospective population‐based cohort study, 7,356 men were included. Prediagnostic WBC and hs‐CRP were assessed ...
    • Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer 

      Flote, Vidar Gordon; Vettukattil, Muhammad Riyas; Bathen, Tone Frost; Egeland, Thore; McTiernan, Anne; Frydenberg, Hanne; Husøy, Anders; Finstad, Sissi Espetvedt; Lømo, Jon; Garred, Øystein; Schlichting, Ellen; Wist, Erik; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)
      <b>Background:</b> High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions is associated with breast tumor characteristics remains unclear.<br> <b>Methods:</b> Among 56 women with newly diagnosed invasive breast cancer stage I/II, aged 35–75 years, pre-surgery overnight fasting serum ...
    • Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women : the Norwegian EBBA-I study 

      Iversen, Anita; Thune, Inger; McTiernan, Anne; Emaus, Aina; Finstad, Sissi Espetvedt; Flote, Vidar Gordon; Wilsgaard, Tom; Lipson, Susan; Ellison, Peter T; Jasienska, Grazyna; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Ovarian hormones, parity and length of ‘menarche-to-first birth’ time interval are known risk factors for breast cancer, yet the associations between 17β-estradiol, progesterone and these reproductive factors remain unclear. A total of 204 women (25–35 years) who participated in the Norwegian EBBA-I study collected daily saliva samples for one complete menstrual cycle, and filled in a reproductive ...
    • Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes 

      Fjeldheim, Frøydis Nyborg; Frydenberg, Hanne; Flote, Vidar Gordon; McTiernan, Anne; Furberg, Anne-Sofie; Ellison, Peter T.; Barrett, Emily S.; Wilsgaard, Tom; Jasienska, Grazyna; Ursin, Giske; Wist, Erik; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-07)
      Background: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1 and premenopausal mammographic density phenotypes is unknown. Methods: ...
    • Systolic and diastolic blood pressure, prostate cancer risk, treatment, and survival. The PROCA-life study 

      Stikbakke, Einar; Schirmer, Henrik; Knutsen, Tore; Støyten, Martin; Wilsgaard, Tom; Giovannucci, Edward L.; McTiernan, Anne; Eggen, Anne Elise; Haugnes, Hege Sagstuen; Richardsen, Elin; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-22)
      Background: Inflammation has been linked to prostate cancer and hypertension, but it remains equivocal whether elevated blood pressure (BP) influence prostate cancer risk and survival.<p> <p>Method: Using Cox regression models, we examined the association between prediagnostic BP and prostate cancer risk among 12,271 men participating in the Prostate Cancer throughout life (PROCA-life) study. ...